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Recent studies have shown that drugs such as metformin, itraconazole and pimobendan have been repositioned to regulate metabolic and epithelial-mesenchymal transition (EMT) pathways, effectively inhibiting BC progression (Kandasamy et al., 2024)

N-acetylcysteine a precursor of the amino acid cysteine that increases glutathione concentration, and is frequently administered to patients infected with HIV

It does not predict glutathione response

doi: 10.1089/can.2016.0027

Given that organelles orchestrate essential intracellular processes, further elucidation of how 4-HNE impairs organelle function in cardiomyocytes may yield novel mechanistic insights and advance therapeutic strategies

Notably, Cys119 and Cys162 have been identified as the principal sites for oxidation and significantly influence the regulatory dynamics of MKK3