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For example, Icarin was confirmed to inhibit ECM degradation and ferroptosis in chondrocytes, thereby alleviating articular cartilage damage in OA rats by restoring SLC7A11 and GPX4 expression (Xiao et al., 2024)

Oncol Lett 21:112 Zhu XL, Chen AF, Lin ZB (2007) Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice

Evaluating each treatment's risks and side effects is also essential, as some people may experience irritation, redness, or increased sensitivity depending on the method used

10.1161/res.0000000000000110 [DOI] [PMC free article] [PubMed] [Google Scholar] Grujicic J, Allen AR (2024) MnSOD mimetics in therapy: exploring their role in combating oxidative stress-related diseases

The protein docking inferences of Regucalcin and Dca versus the 14-3-3 protein epsilon, Histidine triad nucleotide-binding protein 1 and Superoxide dismutase 1 here made show that this is a possibility, although the predicted Dca and Regucalcin interacting regions are different (Additional file 1: Fig

So having said this, it's the secret sauce