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In TRIF-dependent signaling pathways of TLR3 and TLR4, the molecular target of EGCG is TANK-binding kinase1 (TBK1), resulting in the decrease of interferon regulatory factor 3 (IRF3) activation, as TBK1 is the downstream kinase of TRIF and phosphorylates IRF3 resulting in its activation (89)

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Tumor cells form a two-way connection with circumferent stroma in the early stage of invasion and after that, tumor-stroma interaction helps the tumor to develop toward metastasis ( Pre-Metastatic Niche An appropriate microenvironment, namely, pre-metastatic niche, can be established in secondary tissues and organs before metastases occurring through a complicated mechanism by interaction between the primary tumors and organs stromal components (92)

A induces reactive oxygen species generation in the liver of male rats

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