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Some researchers propose that B12 influences neurotransmitter metabolism in the chemoreceptor trigger zone of the brainstem

That is not opinion

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If your body is already severely lacking in vitamin B12, it might be too late to rely on oral supplements or eating foods high in vitamin B12

While dietary sources such as meat, seafood, and animal products typically provide sufficient Vitamin B12, some individualsespecially those with dietary restrictions or absorption issuesmay experience deficiencies

The rationale for utilizing different conventional B12 supplement at each center, for comparison with Sucrosomial B12, was to ensure the reproducibility of study outcomes amidst the variability in B12 formulations