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A disruption of the guiding bar might therefore lead to a higher flexibility of the C-terminal arm

it means the substance has not gone through the drug-approval process, so claims about therapeutic effectiveness should be read critically

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Gastroenterology 151:616632

doi: 10.1046/j.1365-2796.1999.00513.x 538 DavidASWesselySPelosiAJ