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However, these combination effects are highly dependent on experimental models and co-administered components: synergistic metabolic improvements have been observed in animal studies (80), whereas some human studies report only modest reductions in liver enzymes without significant changes in broader metabolic parameters (64)

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While several double-blind RCTs demonstrate therapeutic potential particularly in reducing hyperactivity, irritability, and enhancing social functionings (Voigt et al., 2024), other trials fail to show benefits on core ASD symptoms (He et al., 2023