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Unfortunately, our current knowledge does not adequately explain what leads to vitreous liquefaction

Pflgers Archiv-Eur J Physiol 472:12731298

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Pharmacological inhibition of vanin-1 using RR6 also did not significantly affect insulin sensitivity or fasting blood glucose levels 42,43

In MCAS, mast cells inappropriately degranulate, releasing a flood of histamine, tryptase, and inflammatory cytokines in response to minor triggers

However, large molecules, hydrophilic compounds, and many therapeutic agents, such as antibodydrug conjugate (ADC), are excluded, limiting the ability of systemic treatment to reach the brain