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During treatment of the PDX model of osteosarcoma, since the individuality of the mice, the tumor volume of one mouse reached 1500 mm 3 by the end of the treatment, and this mouse was not euthanized in time to obtain reliable and intuitive experimental results

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10.1186/s13014-020-01735-9 281 LiuJ.NingW.ZhangN.ZhuB.MaoY

For instance, transferrin receptor 1 (TFRC) mediates Fe 3+ uptake, while divalent metal transporter 1 (DMT1) facilitates Fe 2+ transport into the cytoplasm

John's Wort: inhibition of human inducible nitric-oxide synthase expression by down- regulating signal transducer and activator of transcription-1 (STAT-1) activation

constructed a biodegradable, cationic phosphoramidederived lipid PL32 and developed noninflammatory PL32 LNPs by incorporating ursolic acid, which enhanced mRNA expression and relieved inflammation via activating vacuolartype ATPase (VATPase) and consequently promoting endosome acidification [84]