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There are two types of BDNF: pro- and mature BDNF, present in the human body (5)

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Since 24 h treatment of adipocytes with an NNMT inhibitor increased intracellular levels of SAM and NAD + , it is likely that prolonged exposures to NNMT inhibitor during differentiation may have resulted in significantly enhanced intracellular flux of SAM and NAD +

As all these dendritic and spine phenotypes have been observed both by exposing the animal to a stressful situation or by administering corticosterone, it is evident that the stress hormone plays a major role in dendrite and spine remodeling

R.NikitopoulouE.Segarra-MondejarM.et al (2021)