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The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion

Nature 402, 769777

In addition, it lowers stress hormones and promotes weight loss

Another more recent study, with participants that had normal cognitive function, noted improvement in only one of three cognitive tests after 12 weeks of taking Lions Mane (26)

The recruitment was primarily from the Psychiatric Clinic, Haukeland University Hospital in Bergen, Norway, with a few patients recruited from other counties