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Thus, triptolide derivatives can overcome the solubility and cytotoxicity limitations of the parent compound, enhancing bioavailability, targeting specificity, and reducing toxicity, while also providing innovative therapeutic modalities such as photodynamic therapy and optical imaging capabilities for improved cancer treatment outcomes

Hypertension reflects chronic RAAS and SNS hyperactivity, with endothelial dysfunction fostering both cardiac stiffness and renal microangiopathy

The level of vitamin C reserves required in man: Towards a solution to the controversy

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The growth rate of the rats also limits the use of the boot for long-term experiments (12 and 20 weeks), where only fully loaded tendons were studied due to concerns about prolonged unloading and its potential impact on animal welfare