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Neurotoxicity research 17, 249256, 10.1007/s12640-009-9099-9 (2010)

Smoking also causes DNA damage and genetic mutations in sperm, making them less able to successfully fertilize eggs

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In addition, IL-1 can strongly upregulates the expression of vascular endothelial cell adhesion molecules and promotes the production of other chemokines, thereby amplifying the recruitment and infiltration of neutrophils and establishing a positive feedback cycle of inflammation (108)