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Moreover, correlation analysis was performed between identified differential ACs and serum ALT (Table 1), demonstrating that increased ACs are significantly and positively correlated to the severity of abnormal liver function ( p 0.05, Figure 7 A), which may explain the absence of changes in SCACs and MCACs in the ALF group compared with the NLF group

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Yet, several clues suggested that additional acetyl-CoA generating mechanisms within the nuclear-cytosolic compartment must exist