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Supplementation of folic acid and vitamin B12 is routinely provided 1 week prior to chemotherapy aiming to minimise its cytotoxic effects, whereas the administration of oral or intravenous dexamethasone does not seem to reduce pemetrexed-associated cutaneous ADRs [4, 5]

Molecular pathways: targeting inhibitor of apoptosis proteins in cancerfrom molecular mechanism to therapeutic application

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Using pure L-carnitine in doses of 2-5 mg/kg/day, monitored by regular lab assessments, delivers effective treatment with minimal safety concerns

Maculopapular eruptions usually appear within 3-20 days of treatment initiation and spontaneously abate within a similar timeframe when medication is discontinued.[6] In this study also all the patients started reaction within 7-10 days of initiating treatment with carbamazepine and which subsided within 5-7 days of discontinuation of treatment