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IN-BDNF Therapies for Neuropsychiatric Disorders Major Depressive Disorder BDNFs dysregulation and depletion, particularly in the hippocampus, is well-demonstrated in both postmortem human brain studies of major depressive disorder (MDD) patients and animal models of depression

A dose of 0.5 mg/kg is presumably still considered to be a predominantly selective dose in the cochlea, whereas doses of 3 and 6 mg/kg could also cause significant MAO-A inhibition

doi: 10.1177/000456329102800503 82 WastneyMEAamodtRLRumbleWFHenkinRI

Blau, S., Rubinstein, A., Bass, P., Singaram, C

10.1080/10408398.2021.1968786 219 SharmaR.BedarkarP.TimalsinaD.ChaudharyA.PrajapatiP

Always consult healthcare professionals before introducing any new supplements to ensure they're appropriate and beneficial