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For instance, disruption of circadian rhythms by repeated advances in the light-dark schedule in rodent models consistently altered expression of core clock genes such as Per2 and Bmal1, leading to impaired immune function, including reduced NK cell cytotoxicity and decreased expression of cytolytic factors like IFN, perforin, and granzyme B

This could lead to enhanced feedback inhibition of growth hormone (GH) secretion and, consequently, reduced IGF-I secretion (21)

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CAT also reacts efficiently with hydrogen donors such as methanol, ethanol, formic acid, or phenols with peroxidase activity

doi: 10.1002/jcp.27360 152 XiaoYXiaJWuSLvZHuangSHuangHet al

DOI: 10.1016/j.pbi.2023.102444