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Higher doses take longer to administer and require closer monitoring, which directly impacts cost

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

These findings raise concerns that high-dose quercetin supplementation could potentially interfere with the metabolism and clearance of co-administered drugs, thereby raising the possibility of clinically relevant drug-drug interactions

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Proulx ST, Engelhardt B