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These findings collectively reveal the previously-unanticipated role of endothelial FAO in heightened retinal vascular leakage, and highlight the potential translational application of GPR30 agonism with Rd to mitigate barrier dysfunction, providing a metabolic regulatory therapeutic strategy for DR

Library sizes were normalised using the trimmed mean of M-values (TMM) method (Robinson & Oshlack, 2010)

In summary, modulating the surface charge of nanoparticles can improve their ability to deliver drugs into the CNS via the endogenous transport mechanism of the BBB

Based on evidence from in vitro and animal studies, microbiome outcomes may differ by cobalamin form and co-intervention

[DOI] [PMC free article] [PubMed] [Google Scholar] Algothmi K.M., Mahasneh Z.M., Abdelnour S.A., Khalaf Q.A., Noreldin A.E., Barkat R.A., Khalifa N.E., Khafaga A.F., Tellez-Isaias G., Alqhtani A.H., Swelum A.A., Abd El-Hack M.E

Association of high-risk human papillomavirus infection duration and cervical lesions with vaginal microbiota composition