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Through the TGF- signaling pathway, miR-29 negatively regulates H4K20me3, an epigenetic target that leads to the progression of senescence (Lyu et al., 2018)

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This ratio remains constant across all degrees of constitutive pigmentation, ranging from the lightest to the darkest complexions and covering the different Fitzpatrick phototypes [8, 9]

Along with (-)-epicatechin-3-sulfate (E3S) and 3-O-methyl-(-)-epicatechin-5/7-sulfate, these three metabolites accounted for the major SREMs detected in human circulation (Ottaviani et al., 2012)