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She presented with severe hypermanganesemia, hepatic Mn accumulation, Mn deposition in the basal ganglia, and clinical manifestations that included an altered gait, mild hepatic cirrhosis, and polycythemia

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Arany S, Cavalcanti L, Phildor D, Watson GE, Kopycka-Kedzierawski DT, Eliav E, Medina-Walpole A, Caprio T Journal of the American Geriatrics Society

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Thus, although more work in animal models are required, the available evidence strongly indicates that IGF-I therapy in Alzheimers dementia may address etiopathogenic processes and could be a potential candidate for clinical trials
