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MDM2, an essential negative regulator of p53 that facilitates the ubiquitination and degradation of the protein, is blocked by MI-219 and MI-77301, which belong to another category of such compounds [324, 325]

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A recent review identified 16 clinical trials associated with ferroptosis, underscoring the growing research focus on therapeutic strategies for iron-dependent lipid peroxidation (Alves et al., 2025)