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The TME is a complex and multi-layered structure, primarily consisting of cancer cells, cancer-associated fibroblasts (CAFs), cells that suppress the immune system (such as tumor-associated macrophages [TAMs], myeloid-derived suppressor cells [MDSCs], and regulatory T cells), cells that activate the immune system (including natural killer [NK] cells, dendritic cells [DCs], and T cells), and a variety of signaling molecules [33,34,35,36]

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This selectivity, combined with a short plasma half-life in animal models, has made ipamorelin a widely used pharmacological tool for isolating GH-axis effects in neuroendocrine, bone-metabolism, body-composition, and gastrointestinal-motility research

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J Phys: Conf Ser