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Polymorphisms in various genes involved in vitamin B 12 metabolism, including the genes encoding the intrinsic factor-cobalamin receptor (60) and the holo-transcobalamin receptor (61), have been associated with increased NTD risk in some studies

Vitamin B-12 helps maintain optimal health and has been shown to be beneficial in helping to reduce fatigue, improve memory, and maintain a healthy body weight

The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig

Evidence on B12 and sleep is mixed: B12 helps regulate circadian rhythm in some contexts, yet high B12 status has been linked with shorter sleep in others

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