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Chem Sci 2018, 9 (38), 75107519

Although the cytotoxicity of TOP1 inhibitors is slightly lower than that of DNA-damaging agents, an optimized linker design achieves a higher DAR with better stability, enhancing the bystander effect

So, going back to the original question of the cash-based PTs, set yourself apart by, I think what you guys do, is having a massive gym there where you can go in and people are doing sled pushes or doing legitimate workouts as part of their PT

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Normally, glutathione alone is not stable
