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Therefore, there is a pressing need for more comprehensive experimental research and follow-up clinical trials to establish robust evidence for their clinical application

doi: 10.1001/archneur.59.10.1541 207 The Parkinson Study Group QE3 InvestigatorsBealMFOakesDShoulsonIHenchcliffeCGalpernWRet al

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Produces measurably lower IGF-1 receptor activation for three converging reasons: accumulated insulin resistance from daily carbohydrate intake, elevated cortisol during the diurnal decline phase, and reduced growth hormone pulsatility

doi: 10.1002/pmic.200701053

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