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Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors

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Upon binding, the receptor-ligand complex initiates intracellular signaling cascades involving pathways such as phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), as well as mitogen-activated protein kinase (MAPK) signaling

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