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Maemondo et al., 2010

Chronic copper peptide exposure without rest periods upregulates MMPs past the remodeling threshold

894 Acid sphingomyelinase (ASM)-mediated autophagy activation is critical for hyperglycemia -induced GPX4 degradation, and inhibition of ASM improves osteogenic function by reducing hyperglycemia-induced GPX4 degradation and subsequent ferroptosis

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Kasolo JN, Bimenya GS, Ojok L, Ochieng J, Ogwal-Okeng JW

Over time, oxidative stress builds up, causing cells to become damaged or worn out
