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Beyond protease resistance, acetylation neutralizes the positive charge at the N-terminus, altering the peptides overall charge distribution and potentially influencing membrane permeability

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Studies have shown that KGFs play a role in regulating the intestinal barrier function by promoting the proliferation and differentiation of gut epithelial cells, and by maintaining the structural integrity of the TJs that form the gut barrier [132]

Furthermore, mechanism of action modulations is described for clinical applicability

The use of generic names also has the advantage of avoiding the confusion that can be generated by the different trade names given to drugs according to their mode of administration and/or therapeutic indication (Table 1)

translational biomarkers) from preclinical efficacy studies to clinical trials (Sommer, 2022)