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The selectivity of FOXO4-DRI appears to be a major advantage: FOXO4-DRI peptide is particularly compelling due to its ability to disrupt the FOXO4-p53 interaction , a critical regulator of cellular senescence

Studies in humans and rodent models of neurodegenerative diseases demonstrate that activating HGF/MET signaling results in cognitive enhancement likely through the potentiation of NMDA currents and increased dendritic arborization 16,25,26