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Ward DM, Kaplan J

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However, the lack of extensive clinical trials specifically targeting its use in pregnant women raises questions about its safety and efficacy

Figure 1 Pharmacodynamic mechanisms Cisplatin modulates several signal transduction pathways involving AKT (v-akt murine thymoma viral oncogene homolog), c-ABL (v-abl Abelson murine leukemia viral oncogene homolog 1), p53, and MAPK (mitogen-activated protein kinase)/JNK (c-Jun NH2-terminal kinase)/ERK (extracellular signal-regulated kinase)

[PMC free article] [PubMed] [Google Scholar] Sebecic B., Nikolic V., Sikiric P., Seiwerth S., Sosa T., Patrlj L., et al