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Preclinical studies have demonstrated that 5-Amino-1MQ effectively reprograms metabolism in key energy-regulating tissues: it counteracts obesity and associated fat accumulation, reduces pathological liver fat, and enhances the regenerative potential of aged skeletal muscle 1-3

NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models