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Yao PY, Alvarado AC, Schaefer TJ

Further study of this clinically relevant route of administration for mitochondria-targeting compounds is warranted in TBI animal models to optimize this route and fully understand dosing, therapeutic window and safety issues related to the route

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Hassan et al

Spermidine/spermine N1-acetyltransferase 1 (SSAT) initiates polyamine catabolism, which decreases the cellular content of polyamines through transferring the acetyl group of acetyl-CoA to either spermidine or spermine, which can be oxidized by peroxisomal enzyme polyamine oxidase (PAOX)