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Importantly, its protection effect was even confirmed in primary human hepatocytes [126]

The coordinated and precise interaction between the ubiquitin-proteasome system (UPS), the protein chaperone system, and the autophagy-lysosome system (ALS) results in a dynamic endogenous protein quality control system that is essential to ensure the protein homeostasis 4,5,6

Azza H, Abou G, Imam MF

Oxidative stress-related genes N-acetyltransferase 2 (NAT2) is involved in the metabolism and detoxification of reactive oxygen species (ROS)

Schizophr 11 , 4 (2025)

Although Bcr-Abl inhibitors such as imatinib, nilotinib, and dasatinib are effective in CML therapy 7,8,9 , the acquisition of the T315I mutation of BCR-ABL in patients causes the resistance to most tyrosine kinase inhibitors (TKI), leading to poor outcomes