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Oxidized TRXs are generally reduced by NADPH-dependent thioredoxin reductases (NTRs), whereas the reduction of GRXs is dependent on glutathione

315 In hyperuricemia, purine-rich diets shift the microbiota toward uric acid producers (e.g., Clostridium spp.), overwhelming renal excretion and triggering crystal formation and fibrosiseffects countered by probiotics such as Lactobacillus rhamnosus, which restore SCFA levels and barrier function

Iron is essential for the de novo production of DNA as a co-factor of ribonucleotide reductase [496]

Proteomics 13(1213):20462062

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder