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Rare hypersensitivity reactions , including cobalt allergy (as cobalamin contains cobalt), have been documented

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During medicinal chemistry optimization, systematic SAR studies on lysine residues are crucial
[PubMed] [Google Scholar] Benovic JL, Regan JW, Matsui H, Mayor F, Jr, Cotecchia S, Leeb-Lundberg LM, Caron MG, Lefkowitz RJ

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