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Taken together, the inhibition of HDAC class I and IIa at a Zn 2+ -dependent catalytic site by BHB results in histone hyperacetylation, particularly at H3K9/K14 and H4K16 residues in gene-promoter regions

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Exp Ther Med 14(2):16691674 Funding The authors extend their appreciation to the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia (Grant No

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