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Development of ROS and GSH responsive nanoparticle-drug delivery systems has been proposed as a way to more specifically and safely deliver highly toxic payload to cancer cells [163]

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6 In a study using intravenous NAC infusion in humans increased histamine levels were found in just a portion of the subjects

[PubMed: 10569655] 828

One significant positive in this study is that they also used laser Doppler scanning (recovery of blood flow in the ischemic muscle) to indicate the promotion of angiogenesis alongside Western blot and real-time PCR for the expression of VEGFR2

doi: 10.1016/j.vaccine.2017.08.069 515 YehTLShihPCLiuSJLinCHLiuJMLeiWTet al