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Experimental data suggest that microbes such as p ks (polyketide synthase)+ Escherichia coli (pks+Ec), ETBF , Fn , and SGG , damage the gut-barrier lining and colonocyte DNA, increase proinflammatory cytokines and oxidative factors, and produce potentially carcinogenic toxins (17, 24, 5861)

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Additionally, dihydrofolate reductase (DHFR) is required for the regeneration of BH4 from its oxidized form, dihydrobiopterin (BH2)

10.1016/S0021-9258(17)41980-6 [DOI] [PubMed] [Google Scholar] [6].Moghimi S.M., Szebeni J