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Experimentally, defective autophagic function resulting from reduced levels or loss of function of BECN1 renders mice lungs more vulnerable to pseudomonas aeruginosa infection (173)

Mitochondrial phosphorylation potential is also decreased in migraine patients due to magnesium deficiency (192)

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However, it is important to recognise that whilst they are widely available, the regulatory framework for food supplements differs significantly from that of licensed medicines, and claims made about their efficacy should be evaluated critically against available evidence

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