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All three domains bind the HCV 3 UTR 17 : DI functions in both genome replication and virus assembly 18,19 , DII is exclusively involved in genome replication 20 and DIII plays a critical role in virion assembly 21

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Hepatocellular Carcinoma (HCC) and Liver Metastases) Viral proteins Proteins Linear polypeptides that are synthesized on ribosomes and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits