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The uncontrolled activation of apoptotic pathways due to intense vibrations of loud sounds contributes to permanent loss of functional cells, impairing hearing

Visser R, Arrabal PM, Santos-Ruiz L, Fernandez-Barranco R, Becerra J, Cifuentes M

Targeted suppression of ferroptosis using compounds like ferrostatin-1 and liproxstatin-1 protects melanocytes from demise, thereby ameliorating vitiligo pathology (133)

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alternatively, R 4a and R 4b , or, R 4a and R 5a , or, R 4a and R 8a form the ring B together with the carbon to which they are bonded