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In many cases they possess an N-terminal signal peptide mediating correct subcellular sorting and trafficking and an anionic propeptide which is thought to be the major contributing factor inhibiting the antimicrobial activity by neutralizing the net positive charge of the mature peptide [19, 20]

MicroRNAs can rapidly establish multidrug resistance barriers by simultaneously repressing multiple apoptosis- or drug transport-related mRNAs [72]

[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L, Singh P, Petukhova L, Mackay-Wiggan J, Christiano AM, Clynes R

Yatsuji S, Hashimoto E, Tobari M, Taniai M, Tokushige K, Shiratori K

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10.1016/j.expneurol.2015.11.010 Exp Neurol