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To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)

There is significant increase in the PP2A levels in the hippocampus of rats treated with donepezil (1.055 0.107, p = 0.0128), FD 50 mg/kg (1.228 0.120, p = 0.0004), FD 100 mg/kg (1.138 0.061, p = 0.0024) and FD 200 mg/kg (1.260 0.051, p = 0.0002) compared to the AD rats induced with D-gal and AlCl 3 (0.647 0.040)

Alpha Lipoic Acid supports cellular antioxidant defence

Sun Y, Han X, Hou Z, et al

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