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Always start with a lower dose if you're unsure

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There appears to be no difference in the strict NO dioxygenation rates of penta- versus hexacoordinate globins (i.e., once the heme is able to bind gaseous ligand, the rates are similar for pentacoordinate globins and hexacoordinate globins), although the rate is limited by the recycling of the heme (238)

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