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Rev Diabet Stud RDS 9(4):338 Olsson A-K et al (2004) The minimal active domain of endostatin is a heparin-binding motif that mediates inhibition of tumor vascularization

So EGF is a plausible cell-renewal signal with a real mechanism, not a guaranteed pigment shield, and a randomized controlled trial of microneedling combined with topical growth factors did report improvements in skin parameters with no adverse effects, which supports the pairing of needling and growth-factor delivery while stopping well short of overpromising

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[DOI] [PubMed] [Google Scholar] 64.Wieseler J, Ellis AL, McFadden A, Brown K, Starnes C, Maier SF, et al

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