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10.24976/Discov.Med.202335177.57 111 ZhangQ.LiJ.LiY.TanG.SunM.ShanY.et al (2022)

The NAD (P)H-FSP1-CoQH 2 /VKH 2 system has been identified as a parallel ferroptosis defense pathway to the SLC7A11-GSH-GPX4 axis in nonmitochondrial environments [73]

N-acetylneuraminate pyruvate-lyase (nanA) in Clostridium is a sialic acid aldolase, and sialic acid is associated with bacterial pathogenicity

The expression levels of caspase 3 and Bax decreased, and those of Bcl-2 increased in the shRNA group, which further confirms that oxalate induces apoptosis in HK-2 cells through activates the NF-B signalling pathway (Fig

The improved insulin sensitivity after GLP-1MK-801 treatment was confirmed in a 2-week study that, in addition to the pharmacological groups, included a calorie-restricted group weight-matched to the GLP-1MK-801 group (Extended Data Fig

Nutritional Deficiencies Longitudinal melanonychia is seen in malnutrition especially protein energy malnutrition and vitamin D deficiency.[24] Vitamin B12 deficiency produces reversible nail pigmentation that can be longitudinal, diffuse bluish or reticulate probably due to reduced glutathione levels resulting in disinhibition of tyrosinase enzyme involved in melanogenesis.[25] Exogenous Pigmentation Brown to black pigmentation of nails can be seen due to exogenous agents like henna, dirt, tobacco, potassium permanganate, tar, and silver nitrate.[16] It presents as a horizontal band with the distal border parallel to the proximal nail fold and tends to move out with the nail plate [Figure 8].[16] Silver nitrate presents with a dark color band with irregular medial border and staining of adjacent skin of nail folds.[16] Syndromes Associated with Melanonychia LaugierHunziker syndrome, Peutz- Jegher and Touraine syndrome are characterized by LM along with pigmented macules in oral mucosa and lips.[7] LM involves several nails, generally finger nails with one or more bands