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First, a systematic search was conducted in PubMed, Web of Science, and Embase from inception to March 2026 using combinations of tinnitus AND (neurodegenerative diseases OR Alzheimer disease OR Parkinson disease) AND (treatment OR therapy OR intervention), supplemented with mechanism-specific terms paired with tinnitus (e.g., neuroinflammation, oxidative stress, BDNF, NMDA receptor, epigenetic)

Biotin helps to improve blood-sugar control

Copper is also capable of causing DNA strand breaks and the oxidation of bases via oxygen-derived free radicals [69]

Furthermore, MDA levels were evaluated as a biomarker of LPO

Vitamin B12 functions as a cofactor for two essential enzymes: methionine synthase (involved in homocysteine metabolism and DNA synthesis) and methylmalonyl-CoA mutase (crucial for fatty acid and amino acid metabolism)

TB500 is investigated for its association with actin polymerization dynamics and intracellular actin sequestration, which directly influences cell motility, differentiation, and structural reorganization