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Cite: Coleman, Y

Did you know that new weight loss medications, such as GLP-1 and GLP-1 & GIP therapies, can make losing weight easier by reducing appetite, regulating blood sugar levels, and increasing your energy levels

A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed

Neuropsychopharmacology 1996;15:45664

Semaglutide disrupts multiple steps in this chain
It is possible that compensatory mechanisms could develop that reduce efficacy with prolonged use
