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Furthermore, by employing the MPTP mouse model to simulate mitochondrial damage and GSH deficiency in PD, we demonstrate that pyridoxine-induced GSH enhancement helpes to reduce the severity of dopaminergic neuron loss and improve some types of mouse locomotion after MPTP administration

Plant Physiol 102:803810 Jeppesen MG, Ortiz P, Shepard W, Kinzy TG, Nyborg J, Andersen GR (2003) The crystal structure of the glutathione S -transferase-like domain of elongation factor 1B gamma from Saccharomyces cerevisiae

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Human phenotyping is facilitated by the GST activity towards methyl bromide or ethylene oxide in erythrocytes which is representative of the metabolic GSTT1 competence of the entire organism

Pathogenesis of Parkinson's disease The pathogenesis of PD arises from a highly integrated network rather than being driven by a single linear pathway

Riboflavin is a B complex vitamin that reduces oxidized glutathione and helps prevent light sensitivity, loss of visual acuity, as well as burning and itching in the eyes (Lopez 1993)