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STAT3 signaling controls cellular senescence and immunosenescence There is clear evidence that insulin/IGF-1 exposure can induce/augment the cellular senescence of different non-immune cells in several experimental conditions [144,145,146,147]

10.1016/j.beem.2013.07.004 Summary Keywords male age, sperm quality, sperm DNA fragmentation index, cumulative pregnancy outcomes, assisted reproductive technology (ART) Citation Xie H, Chen Y, Xu S, Miao N, Zheng W, Jiang C and Sun T (2025) Increasing age in men is negatively associated with sperm quality and DNA integrity but not pregnancy outcomes in assisted reproductive technology

Atg13 is essential for autophagy and cardiac development in mice

This can help with testosterone survival, sperm motility, and sexual function

As our understanding grows, interventions that once seemed counterintuitive (like using pro-oxidants or leveraging glycan signals) may become part of the armamentarium against IBD

Fuschi, D